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Leukopenia Thrombocytopenia Tumor cell infiltration of bone marrow Previous X-ray therapy Previous therapy with other cytotoxic agents Impaired hepatic function Impaired renal function.

This drug passes into breast milk and may harm a nursing infantBreast-feeding while using this drug is not recommendedConsult your doctor before breast-feeding.

Increased hematotoxicity and/or immunosuppression may result from a combined effect of cyclophosphamide andfor exampleACE inhibitorsACE inhibitors can cause leukopeniaNatalizumab PaclitaxelIncreased hematotoxicity has been reported when cyclophosphamide was administered after paclitaxel infusionThiazide diuretics Zidovudine Increased cardiotoxicity may result from a combined effect of cyclophosphamide andfor exampleAnthracyclines Cytarabine Pentostatin Radiation therapy of the cardiac region Trastuzumab Increased pulmonarytoxicity may result from a combined effect of cyclophosphamide andfor exampleAmiodarone G-CSFGM-CSFgranulocyte colony-stimulating factorgranulocytemacrophagecolony-stimulating factorReports suggest an increased risk of pulmonary toxicity in patients treated with cytotoxic chemotherapy that includes cyclophosphamide and G-CSF or GMCSFIncreased nephrotoxicity may result from a combined effect of cyclophosphamide andfor exampleAmphotericin B IndomethacinAcute water intoxication has been reported with concomitant use of indomethacin Increase in other toxicitiesAzathioprineIncreased risk of hepatotoxicityliver necrosisBusulfanIncreased incidence of hepatic veno-occlusive disease and mucositis has been reportedProtease inhibitorsIncreased incidence of mucositis Increased risk of hemorrhagic cystitis may result from a combined effect of cyclophosphamide and past or concomitant radiation treatment.

The following adverse reactions have been identified from clinical trials or post-marketing surveillanceBecause they are reported from a population from unknown sizeprecise estimates of frequency cannot be made.

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